Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Tier1-Fuchs Exclusive	HPO	4.26e-02	4.61e-02	5.22e-02	1.91e-10
HPO Exclusive	Tier1-Fuchs	2.24e-04	1.08e-03	1.77e-05	1.20e-04
Tier1-Fuchs Exclusive	HPO Exclusive	2.07e-01	2.86e-01	1.82e-01	1.40e-09
HPO Exclusive	Tier1-Fuchs Exclusive	7.60e-02	1.10e-01	5.46e-02	1.78e-01
Tier1-Fuchs Exclusive	Overlap	1.50e-05	9.81e-06	9.81e-06	1.02e-05
HPO Exclusive	Overlap	2.62e-06	3.28e-06	2.62e-06	3.59e-06
Overlap	Exclusives	5.47e-07	5.51e-08	2.16e-23	4.07e-15



Evaluating how well Tier1-Fuchs genes are linked to HPO genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Tier1-Fuchs Exclusive	HPO	0.66	0.71	2.66	0.66	6.92
HPO Exclusive	Tier1-Fuchs	0.79	3.20	3.69	2.97	3.92
Tier1-Fuchs Exclusive	HPO Exclusive	0.65	0.62	1.87	0.55	5.17
HPO Exclusive	Tier1-Fuchs Exclusive	0.64	2.07	2.26	1.86	1.44
Tier1-Fuchs Exclusive	Overlap	0.98	3.19	4.48	3.04	3.85
HPO Exclusive	Overlap	0.99	3.00	4.15	3.46	4.53
Overlap	Exclusives	0.72	2.48	7.19	2.75	9.55

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Tier1-Fuchs Exclusive	HPO	0.02	2.49	7.57	1.58	9.70
HPO Exclusive	Tier1-Fuchs	0.01	21.34	6.78	31.52	12.03
Tier1-Fuchs Exclusive	HPO Exclusive	0.01	1.66	3.69	0.81	3.96
HPO Exclusive	Tier1-Fuchs Exclusive	0.00	2.56	0.85	2.32	0.24
Tier1-Fuchs Exclusive	Overlap	0.01	28.52	40.28	25.92	14.57
HPO Exclusive	Overlap	0.02	10.09	12.85	41.02	77.61
Overlap	Exclusives	0.05	6.99	38.71	18.03	53.98

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Tier1-Fuchs Exclusive	8	8	
HPO Exclusive	152	149	PWRN1;SNORD116-1;SNORD115-1
Overlap	6	6