Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Tier1-Fuchs Exclusive	CMDKP-T2D	6.04e-07	1.89e-08	8.15e-14	2.38e-10
CMDKP-T2D Exclusive	Tier1-Fuchs	1.33e-06	4.35e-06	2.15e-07	9.33e-07
Tier1-Fuchs Exclusive	CMDKP-T2D Exclusive	1.67e-06	8.14e-08	1.65e-12	1.57e-09
CMDKP-T2D Exclusive	Tier1-Fuchs Exclusive	4.34e-06	5.87e-06	4.95e-07	7.44e-07
Tier1-Fuchs Exclusive	Overlap	7.08e-02	6.92e-02	1.04e-02	7.40e-02
CMDKP-T2D Exclusive	Overlap	7.74e-02	8.45e-02	7.57e-02	9.62e-02
Overlap	Exclusives	1.55e-05	7.59e-07	1.84e-04	2.22e-09



Evaluating how well Tier1-Fuchs genes are linked to CMDKP-T2D genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Tier1-Fuchs Exclusive	CMDKP-T2D	0.68	6.07	7.00	5.79	8.48
CMDKP-T2D Exclusive	Tier1-Fuchs	0.85	4.93	4.48	3.93	4.91
Tier1-Fuchs Exclusive	CMDKP-T2D Exclusive	0.68	4.79	6.27	4.93	7.88
CMDKP-T2D Exclusive	Tier1-Fuchs Exclusive	0.99	5.30	4.29	4.28	4.52
Tier1-Fuchs Exclusive	Overlap	0.78	2.83	2.74	2.87	2.49
CMDKP-T2D Exclusive	Overlap	0.68	2.74	2.24	1.96	1.66
Overlap	Exclusives	0.66	2.80	5.10	3.15	6.94

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Tier1-Fuchs Exclusive	CMDKP-T2D	0.06	38.72	79.01	47.01	79.49
CMDKP-T2D Exclusive	Tier1-Fuchs	0.07	168.39	215.05	188.68	182.99
Tier1-Fuchs Exclusive	CMDKP-T2D Exclusive	0.04	19.71	54.55	39.17	48.81
CMDKP-T2D Exclusive	Tier1-Fuchs Exclusive	0.05	107.27	176.16	174.37	119.58
Tier1-Fuchs Exclusive	Overlap	0.18	150.14	666.70	86.81	65.40
CMDKP-T2D Exclusive	Overlap	0.02	118.71	92.99	60.30	84.88
Overlap	Exclusives	0.03	12.41	28.40	17.19	28.85

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Tier1-Fuchs Exclusive	8	8	
CMDKP-T2D Exclusive	149	144	CTD-2021H9.3;AL627309.1;AL117190.2;AC022431.2;CTC-236F12.4
Overlap	6	6