Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Tier1-Glycemic Exclusive	CMDKP-T2D	5.88e-07	6.46e-07	7.85e-13	8.56e-10
CMDKP-T2D Exclusive	Tier1-Glycemic	1.12e-09	2.09e-09	6.21e-15	5.74e-16
Tier1-Glycemic Exclusive	CMDKP-T2D Exclusive	1.32e-03	4.18e-04	5.03e-10	8.75e-07
CMDKP-T2D Exclusive	Tier1-Glycemic Exclusive	2.19e-06	1.50e-06	3.12e-10	1.42e-11
Tier1-Glycemic Exclusive	Overlap	1.30e-10	6.54e-10	3.35e-12	3.73e-11
CMDKP-T2D Exclusive	Overlap	2.55e-08	1.33e-07	6.22e-09	1.57e-08
Overlap	Exclusives	7.09e-13	1.99e-14	2.06e-17	7.55e-16



Evaluating how well Tier1-Glycemic genes are linked to CMDKP-T2D genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Tier1-Glycemic Exclusive	CMDKP-T2D	0.68	6.52	7.48	6.51	7.38
CMDKP-T2D Exclusive	Tier1-Glycemic	0.73	6.13	7.36	5.50	9.83
Tier1-Glycemic Exclusive	CMDKP-T2D Exclusive	0.65	5.33	4.99	5.45	5.88
CMDKP-T2D Exclusive	Tier1-Glycemic Exclusive	0.70	5.11	6.04	4.46	6.93
Tier1-Glycemic Exclusive	Overlap	0.92	5.69	6.16	4.82	6.26
CMDKP-T2D Exclusive	Overlap	0.90	5.34	5.86	4.30	6.39
Overlap	Exclusives	0.68	6.34	7.62	6.11	9.10

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Tier1-Glycemic Exclusive	CMDKP-T2D	0.07	54.98	53.26	56.25	69.56
CMDKP-T2D Exclusive	Tier1-Glycemic	0.05	31.82	48.63	40.68	51.61
Tier1-Glycemic Exclusive	CMDKP-T2D Exclusive	0.02	8.36	14.48	10.69	8.92
CMDKP-T2D Exclusive	Tier1-Glycemic Exclusive	0.03	13.84	24.12	19.69	14.16
Tier1-Glycemic Exclusive	Overlap	0.26	631.46	558.30	674.61	630.33
CMDKP-T2D Exclusive	Overlap	0.06	156.49	138.11	129.73	184.85
Overlap	Exclusives	0.07	48.79	67.56	49.97	70.89

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Tier1-Glycemic Exclusive	124	119	LINC00261;LOC157273;LOC440028;LOC101928448;LOC101928994
CMDKP-T2D Exclusive	138	133	CTD-2021H9.3;AL627309.1;AL117190.2;AC022431.2;CTC-236F12.4
Overlap	17	17