Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Tier1-Glycemic Exclusive	MalaCard-BMI	1.53e-09	1.11e-09	1.18e-12	6.96e-12
MalaCard-BMI Exclusive	Tier1-Glycemic	3.79e-06	1.11e-04	1.15e-06	4.05e-11
Tier1-Glycemic Exclusive	MalaCard-BMI Exclusive	2.95e-09	2.49e-09	2.06e-11	3.16e-10
MalaCard-BMI Exclusive	Tier1-Glycemic Exclusive	1.18e-05	1.52e-04	4.44e-06	4.25e-10
Tier1-Glycemic Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.22e-02
MalaCard-BMI Exclusive	Overlap	1.15e-02	1.82e-02	1.15e-02	1.35e-02
Overlap	Exclusives	7.28e-18	1.37e-15	8.01e-44	1.57e-20



Evaluating how well Tier1-Glycemic genes are linked to MalaCard-BMI genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Tier1-Glycemic Exclusive	MalaCard-BMI	0.93	3.18	5.46	3.08	6.10
MalaCard-BMI Exclusive	Tier1-Glycemic	0.70	3.38	5.33	3.75	8.50
Tier1-Glycemic Exclusive	MalaCard-BMI Exclusive	0.92	3.29	5.54	2.93	5.30
MalaCard-BMI Exclusive	Tier1-Glycemic Exclusive	0.69	3.58	4.94	3.93	6.84
Tier1-Glycemic Exclusive	Overlap	1.00	2.41	1.81	1.98	2.59
MalaCard-BMI Exclusive	Overlap	1.00	2.33	2.10	2.48	2.70
Overlap	Exclusives	0.76	3.97	8.86	3.78	11.52

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Tier1-Glycemic Exclusive	MalaCard-BMI	0.04	35.26	71.22	42.70	95.23
MalaCard-BMI Exclusive	Tier1-Glycemic	0.02	8.25	13.71	12.84	15.67
Tier1-Glycemic Exclusive	MalaCard-BMI Exclusive	0.02	19.64	48.09	23.75	35.74
MalaCard-BMI Exclusive	Tier1-Glycemic Exclusive	0.02	8.84	11.16	10.55	15.83
Tier1-Glycemic Exclusive	Overlap	0.08	53.49	109.08	230.82	47.31
MalaCard-BMI Exclusive	Overlap	0.02	21.31	35.85	76.29	43.05
Overlap	Exclusives	0.06	30.17	25.01	26.94	92.94

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Tier1-Glycemic Exclusive	139	134	LOC101928994;LOC440028;LOC101928448;LOC157273;LINC00261
MalaCard-BMI Exclusive	15	15	
Overlap	2	2