Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
MalaCard-T2D Exclusive	CMDKP-T2D	8.70e-06	3.89e-04	1.32e-07	6.86e-06
CMDKP-T2D Exclusive	MalaCard-T2D	2.07e-13	9.43e-15	5.75e-18	6.37e-19
MalaCard-T2D Exclusive	CMDKP-T2D Exclusive	1.16e-03	2.00e-02	1.03e-05	2.83e-04
CMDKP-T2D Exclusive	MalaCard-T2D Exclusive	3.78e-09	1.44e-09	4.33e-12	6.67e-13
MalaCard-T2D Exclusive	Overlap	4.18e-08	4.18e-08	4.18e-08	4.99e-08
CMDKP-T2D Exclusive	Overlap	8.42e-08	1.35e-07	4.77e-08	6.78e-08
Overlap	Exclusives	1.14e-10	3.29e-09	2.83e-19	3.36e-12



Evaluating how well MalaCard-T2D genes are linked to CMDKP-T2D genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
MalaCard-T2D Exclusive	CMDKP-T2D	0.64	4.78	4.16	4.06	6.65
CMDKP-T2D Exclusive	MalaCard-T2D	0.94	4.94	7.45	4.98	7.84
MalaCard-T2D Exclusive	CMDKP-T2D Exclusive	0.62	3.09	3.24	3.20	4.84
CMDKP-T2D Exclusive	MalaCard-T2D Exclusive	0.93	4.04	6.41	4.18	7.19
MalaCard-T2D Exclusive	Overlap	1.00	3.96	4.96	4.26	4.77
CMDKP-T2D Exclusive	Overlap	0.99	3.19	4.77	3.07	4.79
Overlap	Exclusives	0.69	6.36	6.85	5.43	8.99

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
MalaCard-T2D Exclusive	CMDKP-T2D	0.05	37.18	31.41	44.95	31.53
CMDKP-T2D Exclusive	MalaCard-T2D	0.06	42.80	104.00	59.95	51.11
MalaCard-T2D Exclusive	CMDKP-T2D Exclusive	0.02	13.87	7.56	16.12	11.24
CMDKP-T2D Exclusive	MalaCard-T2D Exclusive	0.03	13.39	47.52	31.17	28.23
MalaCard-T2D Exclusive	Overlap	0.26	236.44	1236.90	850.78	430.36
CMDKP-T2D Exclusive	Overlap	0.06	89.22	210.19	122.46	69.66
Overlap	Exclusives	0.07	68.18	61.61	69.23	69.57

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
MalaCard-T2D Exclusive	24	24	
CMDKP-T2D Exclusive	147	142	CTD-2021H9.3;AL627309.1;CTC-236F12.4;AC022431.2;AL117190.2
Overlap	8	8