Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
T2D-Consensus2 Exclusive	MalaCard-BMI	1.65e-11	6.13e-10	3.95e-13	2.89e-12
MalaCard-BMI Exclusive	T2D-Consensus2	5.36e-16	7.53e-16	5.77e-18	1.42e-20
T2D-Consensus2 Exclusive	MalaCard-BMI Exclusive	8.04e-10	2.46e-08	7.64e-11	1.11e-09
MalaCard-BMI Exclusive	T2D-Consensus2 Exclusive	1.53e-13	9.20e-14	1.73e-16	3.81e-19
T2D-Consensus2 Exclusive	Overlap	1.38e-03	1.38e-03	1.38e-03	1.38e-03
MalaCard-BMI Exclusive	Overlap	1.38e-03	1.60e-03	1.38e-03	1.68e-03
Overlap	Exclusives	1.59e-35	3.10e-34	2.65e-36	1.81e-35



Evaluating how well T2D-Consensus2 genes are linked to MalaCard-BMI genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
T2D-Consensus2 Exclusive	MalaCard-BMI	0.94	3.69	5.78	3.16	6.43
MalaCard-BMI Exclusive	T2D-Consensus2	0.90	4.78	8.79	4.66	10.46
T2D-Consensus2 Exclusive	MalaCard-BMI Exclusive	0.93	3.32	4.92	2.91	4.99
MalaCard-BMI Exclusive	T2D-Consensus2 Exclusive	0.89	4.07	9.11	4.90	10.73
T2D-Consensus2 Exclusive	Overlap	1.00	2.29	2.99	2.82	2.79
MalaCard-BMI Exclusive	Overlap	0.99	4.10	2.71	3.22	2.86
Overlap	Exclusives	0.94	3.97	11.79	3.33	13.11

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
T2D-Consensus2 Exclusive	MalaCard-BMI	0.05	43.50	76.70	59.52	107.28
MalaCard-BMI Exclusive	T2D-Consensus2	0.03	8.91	48.31	19.84	31.71
T2D-Consensus2 Exclusive	MalaCard-BMI Exclusive	0.02	37.83	34.61	29.43	33.18
MalaCard-BMI Exclusive	T2D-Consensus2 Exclusive	0.02	9.83	38.83	19.88	37.43
T2D-Consensus2 Exclusive	Overlap	0.07	41.02	318.26	155.53	102.81
MalaCard-BMI Exclusive	Overlap	0.01	95.03	48.25	69.35	16.78
Overlap	Exclusives	0.11	71.74	185.80	50.72	63.00

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
T2D-Consensus2 Exclusive	47	47	
MalaCard-BMI Exclusive	14	14	
Overlap	3	3