Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
wavelet Exclusive	AD-GS	1.07e-01	7.25e-02	9.73e-08	1.15e-04
AD-GS Exclusive	wavelet	1.02e-03	1.08e-01	5.40e-06	5.21e-13
wavelet Exclusive	AD-GS Exclusive	1.26e-01	5.83e-02	4.63e-07	1.39e-03
AD-GS Exclusive	wavelet Exclusive	1.24e-03	1.37e-01	7.16e-06	7.78e-13
wavelet Exclusive	Overlap	4.76e-01	5.40e-01	1.15e-02	2.55e-02
AD-GS Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.15e-02
Overlap	Exclusives	4.40e-02	1.45e-04	1.17e-57	1.40e-31



Evaluating how well wavelet genes are linked to AD-GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wavelet Exclusive	AD-GS	0.71	1.85	2.21	1.23	4.25
AD-GS Exclusive	wavelet	0.68	-0.76	1.23	-0.33	7.93
wavelet Exclusive	AD-GS Exclusive	0.69	1.84	1.50	1.31	2.78
AD-GS Exclusive	wavelet Exclusive	0.67	-0.69	1.10	-0.40	9.40
wavelet Exclusive	Overlap	0.96	0.91	0.64	1.85	1.99
AD-GS Exclusive	Overlap	1.00	2.50	2.42	2.53	2.54
Overlap	Exclusives	0.74	-0.48	3.76	1.67	13.11

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wavelet Exclusive	AD-GS	0.00	2.39	1.03	1.81	1.81
AD-GS Exclusive	wavelet	0.02	2.14	4.14	3.56	9.14
wavelet Exclusive	AD-GS Exclusive	0.00	2.81	2.07	1.07	1.46
AD-GS Exclusive	wavelet Exclusive	0.02	1.48	3.77	3.29	7.80
wavelet Exclusive	Overlap	0.00	1.17	-8.26	2.94	0.34
AD-GS Exclusive	Overlap	0.04	125.15	205.76	221.64	73.56
Overlap	Exclusives	0.05	15.58	24.39	9.83	43.36

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
wavelet Exclusive	193	193	
AD-GS Exclusive	23	22	HLA -DRB1
Overlap	2	2