Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
wavelet Exclusive	singleton	7.46e-01	8.13e-01	5.97e-05	1.68e-03
singleton Exclusive	wavelet	7.86e-06	8.69e-01	1.74e-09	2.87e-19
wavelet Exclusive	singleton Exclusive	8.80e-01	7.74e-01	3.45e-04	5.71e-03
singleton Exclusive	wavelet Exclusive	7.42e-06	8.99e-01	1.68e-11	2.17e-19
wavelet Exclusive	Overlap	1.33e-01	7.14e-01	9.92e-02	1.49e-01
singleton Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
Overlap	Exclusives	5.29e-06	1.61e-08	1.84e-35	3.00e-31



Evaluating how well wavelet genes are linked to singleton genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wavelet Exclusive	singleton	0.74	-0.52	-1.00	0.80	3.79
singleton Exclusive	wavelet	0.70	-2.32	0.12	0.61	9.61
wavelet Exclusive	singleton Exclusive	0.73	-0.75	-1.08	0.54	4.15
singleton Exclusive	wavelet Exclusive	0.70	-2.25	-0.01	0.87	12.40
wavelet Exclusive	Overlap	0.91	1.18	0.50	0.89	1.42
singleton Exclusive	Overlap	1.00	2.25	2.16	1.86	1.70
Overlap	Exclusives	0.76	0.93	5.08	1.79	14.26

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wavelet Exclusive	singleton	0.00	-0.95	-5.92	1.13	5.03
singleton Exclusive	wavelet	0.02	-1.09	0.56	1.94	8.06
wavelet Exclusive	singleton Exclusive	0.00	-1.00	-6.11	0.64	5.98
singleton Exclusive	wavelet Exclusive	0.02	-1.47	-0.11	1.68	11.80
wavelet Exclusive	Overlap	0.00	0.79	-0.22	0.30	1.17
singleton Exclusive	Overlap	0.06	433.11	351.14	160.57	52.77
Overlap	Exclusives	0.03	2.13	9.81	3.00	19.65

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
wavelet Exclusive	194	194	
singleton Exclusive	20	20	
Overlap	1	1