Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EPI	singleton	2.01e-02	3.77e-01	9.50e-02	1.66e-02
singleton	EPI	2.74e-01	7.01e-01	5.01e-05	9.90e-01



Evaluating how well EPI genes are linked to singleton genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI	singleton	0.63	-1.22	-0.54	-0.83	2.10
singleton	EPI	0.49	-0.06	-1.50	-1.19	-0.32

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI	singleton	0.00	-1.23	-0.88	-0.86	0.39
singleton	EPI	0.01	-0.31	-1.37	-1.19	-0.42

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EPI	110	109	PNMA6F
singleton	21	21