Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EPI	Ismael	8.65e-02	2.54e-01	4.14e-01	3.68e-01
Ismael	EPI	1.19e-01	5.08e-01	5.99e-04	6.32e-01



Evaluating how well EPI genes are linked to Ismael genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI	Ismael	0.59	-1.47	-1.11	-0.57	1.07
Ismael	EPI	0.50	0.48	-0.87	-0.71	0.07

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI	Ismael	0.00	-1.01	-0.57	-0.26	0.05
Ismael	EPI	0.01	-0.19	-1.22	-0.77	-0.39

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EPI	110	109	PNMA6F
Ismael	14	14