Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EAML	Juan GS	6.55e-02	5.92e-01	6.24e-02	1.01e-02
Juan GS	EAML	6.94e-01	5.04e-01	5.47e-16	2.49e-03



Evaluating how well EAML genes are linked to Juan GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML	Juan GS	0.74	-0.85	0.32	-0.55	2.97
Juan GS	EAML	0.45	0.06	-0.78	-0.20	-2.78

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML	Juan GS	0.00	-1.08	-0.82	-1.12	1.32
Juan GS	EAML	0.01	-0.30	-0.71	-0.40	-1.22

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EAML	219	216	PNMA6F;AC091959.3;BX276092.9
Juan GS	12	12