Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EAML Exclusive	LBD	5.69e-01	5.40e-01	7.21e-01	1.84e-02
LBD Exclusive	EAML	1.63e-02	4.86e-01	4.48e-26	1.27e-02
EAML Exclusive	LBD Exclusive	5.60e-01	9.55e-01	5.14e-01	9.22e-02
LBD Exclusive	EAML Exclusive	1.23e-02	4.95e-01	6.65e-25	2.44e-02
EAML Exclusive	Overlap	1.12e-01	9.92e-02	2.65e-01	1.12e-01
LBD Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	1.18e-01
Overlap	Exclusives	5.13e-02	5.08e-01	2.74e-35	6.35e-02



Evaluating how well EAML genes are linked to LBD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML Exclusive	LBD	0.77	-0.26	0.55	-0.06	2.38
LBD Exclusive	EAML	0.46	1.04	0.28	0.18	-2.30
EAML Exclusive	LBD Exclusive	0.73	-0.51	0.23	-0.40	1.76
LBD Exclusive	EAML Exclusive	0.46	0.92	0.21	0.04	-1.89
EAML Exclusive	Overlap	0.98	0.91	170462470212057.00	0.54	1.65
LBD Exclusive	Overlap	0.99	2.89	358648434489119.00	2.14	1.52
Overlap	Exclusives	0.47	-129348987220156.00	0.95	0.22	-1.35

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML Exclusive	LBD	0.00	-0.13	0.98	-0.64	1.69
LBD Exclusive	EAML	0.01	0.29	-0.06	0.03	-1.08
EAML Exclusive	LBD Exclusive	0.00	-0.71	-0.01	-0.97	1.24
LBD Exclusive	EAML Exclusive	0.01	0.00	-0.27	-0.18	-0.93
EAML Exclusive	Overlap	0.00	1.32	12640017707141504.00	-0.18	3.95
LBD Exclusive	Overlap	0.00	15.97	inf	13.22	1.78
Overlap	Exclusives	0.02	inf	8.76	3.35	5.30

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EAML Exclusive	218	215	AC091959.3;BX276092.9;PNMA6F
LBD Exclusive	5	5	
Overlap	1	1