Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Reactome Exclusive	Juan GS	7.19e-02	2.02e-01	3.19e-01	2.62e-02
Juan GS Exclusive	Reactome	2.94e-02	1.70e-01	1.03e-31	5.27e-05
Reactome Exclusive	Juan GS Exclusive	5.78e-02	6.00e-01	1.76e-01	4.18e-02
Juan GS Exclusive	Reactome Exclusive	1.64e-02	1.36e-01	8.65e-28	6.32e-05
Reactome Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
Juan GS Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
Overlap	Exclusives	1.23e-41	5.59e-24	2.72e-68	5.10e-34



Evaluating how well Reactome genes are linked to Juan GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Reactome Exclusive	Juan GS	0.72	-0.91	0.98	-0.76	2.62
Juan GS Exclusive	Reactome	0.55	0.38	-1.05	-0.22	2.36
Reactome Exclusive	Juan GS Exclusive	0.69	-1.10	0.20	-0.96	3.11
Juan GS Exclusive	Reactome Exclusive	0.54	0.15	-1.10	-0.49	2.30
Reactome Exclusive	Overlap	0.99	1.18	2.14	1.71	2.13
Juan GS Exclusive	Overlap	1.00	2.54	1.81	2.07	2.08
Overlap	Exclusives	0.79	2.63	13.02	2.30	15.31

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Reactome Exclusive	Juan GS	0.00	-0.93	1.20	-0.87	2.87
Juan GS Exclusive	Reactome	0.01	0.05	-1.34	-0.42	0.06
Reactome Exclusive	Juan GS Exclusive	0.00	-1.19	-0.44	-1.31	0.16
Juan GS Exclusive	Reactome Exclusive	0.01	-0.28	-1.63	-0.60	-0.14
Reactome Exclusive	Overlap	0.00	2.97	14.28	21.82	34.77
Juan GS Exclusive	Overlap	0.02	251.83	123.50	82.31	17.23
Overlap	Exclusives	0.06	7.56	64.43	8.28	56.64

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Reactome Exclusive	181	180	GBA3
Juan GS Exclusive	11	11	
Overlap	1	1