Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Reactome	Juan SS 	9.37e-02	7.16e-01	2.62e-01	8.21e-01
Juan SS 	Reactome	5.91e-01	1.12e-01	4.19e-01	6.17e-05



Evaluating how well Reactome genes are linked to Juan SS  genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Reactome	Juan SS 	0.55	-0.31	0.56	-0.15	0.46
Juan SS 	Reactome	0.54	-0.02	-2.31	-0.39	1.87

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Reactome	Juan SS 	0.00	-0.39	-0.05	-0.46	-0.23
Juan SS 	Reactome	0.01	-0.25	-1.79	-0.54	-0.23

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Reactome	182	181	GBA3
Juan SS 	11	11