Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Reactome	Ismeal	9.76e-01	1.26e-01	6.05e-01	2.46e-04
Ismeal	Reactome	1.35e-03	4.62e-02	4.22e-17	4.93e-09



Evaluating how well Reactome genes are linked to Ismeal genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Reactome	Ismeal	0.78	1.02	2.28	1.39	4.01
Ismeal	Reactome	0.61	1.92	1.88	0.61	4.75

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Reactome	Ismeal	0.00	-0.70	1.18	-0.13	0.87
Ismeal	Reactome	0.01	0.53	0.54	0.24	2.53

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Reactome	182	181	GBA3
Ismeal	14	14