Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
v2_EPI	BMI	2.89e-01	2.42e-01	5.44e-01	1.61e-02
BMI	v2_EPI	1.26e-02	3.20e-01	9.10e-02	6.39e-01



Evaluating how well v2_EPI genes are linked to BMI genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
v2_EPI	BMI	0.69	0.87	1.46	0.42	3.08
BMI	v2_EPI	0.51	2.01	1.71	1.37	0.50

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
v2_EPI	BMI	0.00	1.21	5.12	0.64	5.09
BMI	v2_EPI	0.01	1.00	0.87	0.81	0.50

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
v2_EPI	192	190	GCSAML-AS1;IQANK1
BMI	17	17