Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
v2_EAW Exclusive	T2D	5.23e-01	4.04e-01	3.61e-11	3.06e-07
T2D Exclusive	v2_EAW	1.38e-05	9.71e-03	1.76e-15	1.13e-19
v2_EAW Exclusive	T2D Exclusive	7.62e-01	1.66e-01	8.81e-11	2.28e-07
T2D Exclusive	v2_EAW Exclusive	1.88e-05	1.37e-02	3.44e-14	2.57e-18
v2_EAW Exclusive	Overlap	2.10e-01	3.24e-01	1.92e-01	1.74e-01
T2D Exclusive	Overlap	1.02e-02	1.02e-02	1.02e-02	1.02e-02
Overlap	Exclusives	1.88e-11	5.80e-08	2.45e-40	1.67e-48



Evaluating how well v2_EAW genes are linked to T2D genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
v2_EAW Exclusive	T2D	0.75	1.36	2.17	2.16	6.02
T2D Exclusive	v2_EAW	0.69	-0.93	2.72	2.18	13.30
v2_EAW Exclusive	T2D Exclusive	0.75	1.38	2.24	1.79	5.95
T2D Exclusive	v2_EAW Exclusive	0.69	-0.88	2.34	2.02	12.80
v2_EAW Exclusive	Overlap	0.76	0.43	0.57	1.26	1.73
T2D Exclusive	Overlap	0.83	1.68	2.57	2.01	2.38
Overlap	Exclusives	0.76	4.31	6.06	2.45	19.05

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
v2_EAW Exclusive	T2D	0.01	1.97	4.28	5.75	15.42
T2D Exclusive	v2_EAW	0.03	0.45	4.97	5.93	14.79
v2_EAW Exclusive	T2D Exclusive	0.01	1.95	2.87	3.94	2.74
T2D Exclusive	v2_EAW Exclusive	0.03	-0.05	2.67	4.76	14.79
v2_EAW Exclusive	Overlap	0.00	2.48	8.65	8.46	0.46
T2D Exclusive	Overlap	0.06	142.71	270.73	72.78	190.22
Overlap	Exclusives	0.06	15.04	22.09	9.68	53.18

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
v2_EAW Exclusive	263	262	SPANXB1
T2D Exclusive	46	46	
Overlap	4	4