Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
v2_Reactome Exclusive	BMI	9.47e-02	1.42e-02	3.24e-03	1.94e-05
BMI Exclusive	v2_Reactome	2.23e-02	5.17e-13	5.99e-18	1.16e-33
v2_Reactome Exclusive	BMI Exclusive	1.60e-01	2.23e-02	3.62e-03	6.81e-05
BMI Exclusive	v2_Reactome Exclusive	2.98e-02	3.39e-13	2.57e-15	3.26e-32
v2_Reactome Exclusive	Overlap	8.35e-02	3.31e-01	1.35e-02	2.10e-02
BMI Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.15e-02
Overlap	Exclusives	1.89e-16	1.57e-17	5.43e-90	3.87e-41



Evaluating how well v2_Reactome genes are linked to BMI genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
v2_Reactome Exclusive	BMI	0.79	1.36	2.84	1.69	5.18
BMI Exclusive	v2_Reactome	0.69	2.19	9.90	2.26	13.75
v2_Reactome Exclusive	BMI Exclusive	0.77	1.47	2.21	1.59	4.08
BMI Exclusive	v2_Reactome Exclusive	0.69	2.00	8.85	2.16	12.49
v2_Reactome Exclusive	Overlap	0.95	0.34	1.45	0.58	2.16
BMI Exclusive	Overlap	1.00	2.26	2.12	2.29	2.34
Overlap	Exclusives	0.73	2.27	10.99	1.60	15.40

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
v2_Reactome Exclusive	BMI	0.00	0.43	2.49	0.65	2.00
BMI Exclusive	v2_Reactome	0.03	1.38	7.94	2.59	12.69
v2_Reactome Exclusive	BMI Exclusive	0.00	0.53	0.68	0.63	1.12
BMI Exclusive	v2_Reactome Exclusive	0.03	1.51	6.68	2.24	10.65
v2_Reactome Exclusive	Overlap	0.00	-0.44	2.66	-0.29	4.50
BMI Exclusive	Overlap	0.03	68.07	73.97	86.45	74.54
Overlap	Exclusives	0.04	3.30	12.12	1.57	19.09

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
v2_Reactome Exclusive	360	359	OPN1MW
BMI Exclusive	15	15	
Overlap	2	2