Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
v2_STRING Exclusive	BMI	8.84e-01	7.28e-01	8.51e-01	7.96e-03
BMI Exclusive	v2_STRING	1.16e-06	9.63e-01	4.54e-10	1.21e-03
v2_STRING Exclusive	BMI Exclusive	9.15e-01	9.18e-01	8.72e-01	1.33e-02
BMI Exclusive	v2_STRING Exclusive	2.48e-07	9.72e-01	3.33e-10	1.62e-03
v2_STRING Exclusive	Overlap	9.36e-01	8.05e-01	9.68e-01	3.92e-01
BMI Exclusive	Overlap	2.10e-05	2.10e-05	2.10e-05	2.30e-05
Overlap	Exclusives	1.05e-05	6.08e-01	9.06e-07	9.91e-03



Evaluating how well v2_STRING genes are linked to BMI genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
v2_STRING Exclusive	BMI	0.69	-0.14	0.72	-0.04	3.29
BMI Exclusive	v2_STRING	0.55	0.75	0.71	0.27	4.07
v2_STRING Exclusive	BMI Exclusive	0.71	-0.27	0.32	0.10	2.53
BMI Exclusive	v2_STRING Exclusive	0.54	0.38	0.40	0.24	3.52
v2_STRING Exclusive	Overlap	0.67	-0.08	0.47	-0.10	1.32
BMI Exclusive	Overlap	1.00	3.14	4.64	2.76	4.22
Overlap	Exclusives	0.53	-0.34	-0.20	-0.62	2.69

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
v2_STRING Exclusive	BMI	0.00	-0.83	-0.08	-0.83	1.52
BMI Exclusive	v2_STRING	0.04	2.60	3.12	1.60	5.49
v2_STRING Exclusive	BMI Exclusive	0.00	-0.75	-0.01	-0.43	1.64
BMI Exclusive	v2_STRING Exclusive	0.04	0.25	-0.08	0.13	2.16
v2_STRING Exclusive	Overlap	0.00	-0.90	-0.32	-0.71	0.02
BMI Exclusive	Overlap	0.37	189.43	918.36	855.17	1499.91
Overlap	Exclusives	0.04	1.97	4.59	1.28	5.78

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
v2_STRING Exclusive	647	645	AC005324.3;IQCJ-SCHIP1
BMI Exclusive	12	12	
Overlap	5	5