Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
v3Train_EPI Exclusive	T2D	3.37e-01	1.58e-01	9.70e-01	2.18e-04
T2D Exclusive	v3Train_EPI	4.96e-05	3.99e-01	2.00e-04	8.24e-01
v3Train_EPI Exclusive	T2D Exclusive	4.60e-01	2.30e-01	9.26e-01	3.69e-05
T2D Exclusive	v3Train_EPI Exclusive	2.53e-05	4.95e-01	3.99e-04	8.75e-01
v3Train_EPI Exclusive	Overlap	4.83e-01	5.93e-01	6.60e-01	5.08e-01
T2D Exclusive	Overlap	6.93e-04	8.38e-04	6.93e-04	8.12e-04
Overlap	Exclusives	1.43e-04	7.02e-04	2.25e-06	4.14e-04



Evaluating how well v3Train_EPI genes are linked to T2D genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
v3Train_EPI Exclusive	T2D	0.68	0.98	1.41	0.43	4.71
T2D Exclusive	v3Train_EPI	0.51	1.49	1.47	1.03	0.55
v3Train_EPI Exclusive	T2D Exclusive	0.70	0.70	0.97	0.11	4.10
T2D Exclusive	v3Train_EPI Exclusive	0.50	1.03	1.34	0.89	0.32
v3Train_EPI Exclusive	Overlap	0.58	0.95	0.66	1.04	0.62
T2D Exclusive	Overlap	0.82	3.65	3.73	3.10	2.97
Overlap	Exclusives	0.55	3.62	5.05	2.71	3.71

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
v3Train_EPI Exclusive	T2D	0.00	0.42	0.13	0.01	4.28
T2D Exclusive	v3Train_EPI	0.03	5.02	5.62	3.55	3.51
v3Train_EPI Exclusive	T2D Exclusive	0.00	0.30	-0.25	-0.32	2.35
T2D Exclusive	v3Train_EPI Exclusive	0.02	0.89	0.87	0.11	-0.33
v3Train_EPI Exclusive	Overlap	0.00	0.21	-0.01	0.23	-0.18
T2D Exclusive	Overlap	0.20	1113.11	959.62	859.22	894.02
Overlap	Exclusives	0.04	11.48	16.98	7.51	11.32

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
v3Train_EPI Exclusive	406	402	GCSAML-AS1;AC018554.3;IQANK1;RNASE4
T2D Exclusive	43	43	
Overlap	7	7