Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) v3Train_EPI BMI 4.47e-01 3.70e-02 6.74e-01 2.17e-03 BMI v3Train_EPI 8.26e-07 3.97e-01 4.12e-04 9.51e-01 Evaluating how well v3Train_EPI genes are linked to BMI genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) v3Train_EPI BMI 0.74 0.89 1.99 0.71 3.50 BMI v3Train_EPI 0.50 1.22 1.16 1.02 0.35 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) v3Train_EPI BMI 0.00 0.19 2.21 0.06 1.29 BMI v3Train_EPI 0.02 0.91 0.81 0.66 0.19 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes v3Train_EPI 413 409 IQANK1;GCSAML-AS1;RNASE4;AC018554.3 BMI 17 17