Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
v3Train_EAW Exclusive	BMI	1.91e-02	2.33e-02	2.07e-08	8.90e-06
BMI Exclusive	v3Train_EAW	4.87e-12	4.75e-02	1.12e-03	4.32e-23
v3Train_EAW Exclusive	BMI Exclusive	1.77e-02	2.94e-02	1.55e-07	1.34e-05
BMI Exclusive	v3Train_EAW Exclusive	5.15e-11	7.33e-02	8.51e-04	8.22e-23
v3Train_EAW Exclusive	Overlap	1.57e-01	3.83e-01	9.92e-02	2.40e-01
BMI Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
Overlap	Exclusives	1.85e-02	1.36e-01	2.69e-40	2.62e-28



Evaluating how well v3Train_EAW genes are linked to BMI genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
v3Train_EAW Exclusive	BMI	0.77	1.78	2.10	1.44	3.79
BMI Exclusive	v3Train_EAW	0.68	-0.94	1.76	-0.18	8.99
v3Train_EAW Exclusive	BMI Exclusive	0.77	1.62	1.83	1.39	3.58
BMI Exclusive	v3Train_EAW Exclusive	0.68	-0.68	1.41	-0.06	9.81
v3Train_EAW Exclusive	Overlap	0.85	1.13	0.45	0.95	1.12
BMI Exclusive	Overlap	1.00	1.88	1.91	2.47	1.84
Overlap	Exclusives	0.71	0.22	1.09	1.11	12.35

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
v3Train_EAW Exclusive	BMI	0.00	2.12	1.79	1.07	3.84
BMI Exclusive	v3Train_EAW	0.02	0.29	3.20	1.56	10.05
v3Train_EAW Exclusive	BMI Exclusive	0.00	1.63	1.77	0.54	3.11
BMI Exclusive	v3Train_EAW Exclusive	0.02	0.32	2.28	1.76	11.54
v3Train_EAW Exclusive	Overlap	0.00	0.94	-0.24	0.27	-0.01
BMI Exclusive	Overlap	0.01	41.37	16.94	102.18	32.42
Overlap	Exclusives	0.03	1.20	4.89	2.06	20.44

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
v3Train_EAW Exclusive	266	265	SPANXB1
BMI Exclusive	16	16	
Overlap	1	1