Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
v3Train_Reactome Exclusive	BMI	1.97e-02	1.45e-02	2.70e-06	3.36e-05
BMI Exclusive	v3Train_Reactome	5.78e-07	6.83e-05	9.72e-06	3.30e-30
v3Train_Reactome Exclusive	BMI Exclusive	1.00e-02	2.02e-02	8.50e-06	2.31e-04
BMI Exclusive	v3Train_Reactome Exclusive	7.11e-07	5.98e-05	4.55e-06	1.80e-31
v3Train_Reactome Exclusive	Overlap	2.00e-02	1.82e-02	1.15e-02	1.49e-02
BMI Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.15e-02
Overlap	Exclusives	2.80e-08	1.88e-09	4.74e-74	1.18e-32



Evaluating how well v3Train_Reactome genes are linked to BMI genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
v3Train_Reactome Exclusive	BMI	0.79	1.42	2.54	1.47	4.28
BMI Exclusive	v3Train_Reactome	0.68	1.15	5.16	1.11	13.53
v3Train_Reactome Exclusive	BMI Exclusive	0.76	1.40	2.03	1.44	3.58
BMI Exclusive	v3Train_Reactome Exclusive	0.68	1.11	5.18	1.30	13.27
v3Train_Reactome Exclusive	Overlap	0.97	0.88	2.70	0.93	2.30
BMI Exclusive	Overlap	1.00	2.16	2.32	2.56	2.71
Overlap	Exclusives	0.70	2.71	6.40	1.60	15.33

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
v3Train_Reactome Exclusive	BMI	0.00	1.40	2.82	1.33	3.52
BMI Exclusive	v3Train_Reactome	0.03	1.19	5.32	1.97	16.35
v3Train_Reactome Exclusive	BMI Exclusive	0.00	1.35	1.43	0.99	0.88
BMI Exclusive	v3Train_Reactome Exclusive	0.03	1.10	5.36	1.78	11.65
v3Train_Reactome Exclusive	Overlap	0.00	0.19	10.02	0.37	7.43
BMI Exclusive	Overlap	0.03	60.84	79.76	109.61	63.71
Overlap	Exclusives	0.04	4.95	10.11	2.09	22.78

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
v3Train_Reactome Exclusive	384	383	CBS
BMI Exclusive	15	15	
Overlap	2	2