Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
v3Train_Consensus2 Exclusive	T2D	2.70e-02	1.33e-01	1.71e-05	2.56e-06
T2D Exclusive	v3Train_Consensus2	2.69e-02	6.05e-02	4.31e-06	1.33e-06
v3Train_Consensus2 Exclusive	T2D Exclusive	4.61e-02	1.72e-01	1.62e-04	9.29e-06
T2D Exclusive	v3Train_Consensus2 Exclusive	4.60e-02	1.41e-01	1.70e-05	2.19e-06
v3Train_Consensus2 Exclusive	Overlap	1.19e-01	3.18e-01	4.46e-02	9.22e-02
T2D Exclusive	Overlap	1.30e-03	1.30e-03	1.30e-03	1.30e-03
Overlap	Exclusives	1.95e-07	1.09e-07	3.53e-13	3.12e-22



Evaluating how well v3Train_Consensus2 genes are linked to T2D genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
v3Train_Consensus2 Exclusive	T2D	0.73	1.90	2.39	2.02	6.06
T2D Exclusive	v3Train_Consensus2	0.62	1.39	2.89	2.07	5.41
v3Train_Consensus2 Exclusive	T2D Exclusive	0.73	1.78	2.14	1.76	5.49
T2D Exclusive	v3Train_Consensus2 Exclusive	0.62	1.25	2.26	2.13	6.05
v3Train_Consensus2 Exclusive	Overlap	0.73	2.10	1.39	1.71	2.18
T2D Exclusive	Overlap	0.86	3.15	2.94	2.62	3.18
Overlap	Exclusives	0.71	3.53	7.47	3.24	12.16

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
v3Train_Consensus2 Exclusive	T2D	0.01	3.98	6.11	5.10	8.30
T2D Exclusive	v3Train_Consensus2	0.03	9.22	15.93	12.65	18.69
v3Train_Consensus2 Exclusive	T2D Exclusive	0.01	4.05	6.18	4.24	11.90
T2D Exclusive	v3Train_Consensus2 Exclusive	0.01	1.50	3.25	3.61	8.09
v3Train_Consensus2 Exclusive	Overlap	0.00	4.27	1.40	2.18	0.19
T2D Exclusive	Overlap	0.30	1640.11	1200.07	258.09	716.36
Overlap	Exclusives	0.04	16.71	35.13	14.80	41.31

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
v3Train_Consensus2 Exclusive	195	191	SPANXB1;IQANK1;RNASE4;GCSAML-AS1
T2D Exclusive	45	45	
Overlap	5	5