Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
v3Train_Consensus2	BMI	1.04e-06	1.77e-06	6.54e-10	3.31e-09
BMI	v3Train_Consensus2	1.19e-03	4.35e-02	6.12e-03	7.01e-06



Evaluating how well v3Train_Consensus2 genes are linked to BMI genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
v3Train_Consensus2	BMI	0.88	2.97	5.27	2.61	5.05
BMI	v3Train_Consensus2	0.61	1.03	2.08	1.08	5.99

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
v3Train_Consensus2	BMI	0.01	6.05	15.05	8.35	17.02
BMI	v3Train_Consensus2	0.02	3.06	5.14	4.54	4.88

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
v3Train_Consensus2	200	196	SPANXB1;GCSAML-AS1;RNASE4;IQANK1
BMI	17	17