Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
v2_Reactome Exclusive	BMI	8.79e-02	1.02e-02	2.17e-03	2.19e-05
BMI Exclusive	v2_Reactome	2.03e-02	9.95e-13	6.03e-19	6.65e-33
v2_Reactome Exclusive	BMI Exclusive	1.89e-01	8.85e-03	8.70e-03	1.18e-04
BMI Exclusive	v2_Reactome Exclusive	2.68e-02	1.21e-12	3.20e-18	2.60e-33
v2_Reactome Exclusive	Overlap	8.35e-02	3.51e-01	1.35e-02	2.21e-02
BMI Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.28e-02
Overlap	Exclusives	3.03e-17	4.69e-17	3.70e-100	2.04e-41



Evaluating how well v2_Reactome genes are linked to BMI genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
v2_Reactome Exclusive	BMI	0.79	1.36	3.12	1.66	4.35
BMI Exclusive	v2_Reactome	0.69	2.21	8.00	1.96	11.14
v2_Reactome Exclusive	BMI Exclusive	0.77	1.43	2.64	1.49	3.70
BMI Exclusive	v2_Reactome Exclusive	0.69	2.28	10.15	2.20	13.37
v2_Reactome Exclusive	Overlap	0.95	0.14	1.45	0.73	1.98
BMI Exclusive	Overlap	1.00	2.33	2.36	2.18	2.57
Overlap	Exclusives	0.73	2.29	10.11	1.75	16.08

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
v2_Reactome Exclusive	BMI	0.00	0.32	1.53	1.13	1.83
BMI Exclusive	v2_Reactome	0.03	1.77	5.60	2.26	10.88
v2_Reactome Exclusive	BMI Exclusive	0.00	0.58	0.87	0.53	0.45
BMI Exclusive	v2_Reactome Exclusive	0.03	1.86	7.25	2.41	10.83
v2_Reactome Exclusive	Overlap	0.00	-0.55	2.86	-0.08	1.59
BMI Exclusive	Overlap	0.03	115.96	74.73	81.04	41.46
Overlap	Exclusives	0.04	3.28	11.73	1.60	19.41

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
v2_Reactome Exclusive	360	359	OPN1MW
BMI Exclusive	15	15	
Overlap	2	2