Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
STRING	Singleton	1.05e-01	6.19e-01	8.00e-04	1.27e-01
Singleton	STRING	5.60e-03	3.14e-02	6.32e-18	2.04e-03



Evaluating how well STRING genes are linked to Singleton genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
STRING	Singleton	0.61	-0.86	-0.24	-1.56	1.78
Singleton	STRING	0.46	0.74	1.56	1.04	-1.92

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
STRING	Singleton	0.00	-0.67	-0.66	-1.05	0.48
Singleton	STRING	0.01	-0.18	-0.11	-0.12	-1.57

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
STRING	156	153	HDGFL2;AC008770.2;CBWD6
Singleton	21	21