Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
STRING	Ismael	2.14e-01	8.41e-01	4.63e-02	5.68e-01
Ismael	STRING	1.90e-05	1.22e-01	6.59e-02	6.10e-06



Evaluating how well STRING genes are linked to Ismael genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
STRING	Ismael	0.59	-0.28	-0.73	-0.91	1.11
Ismael	STRING	0.39	-2.10	-2.11	-0.91	-5.05

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
STRING	Ismael	0.00	-0.25	-0.93	-0.70	0.21
Ismael	STRING	0.01	-1.27	-0.60	-0.85	-1.69

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
STRING	156	153	AC008770.2;CBWD6;HDGFL2
Ismael	14	14