Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
STRING	AD GS	9.94e-02	3.71e-01	1.27e-03	2.90e-02
AD GS	STRING	3.17e-03	5.33e-02	2.11e-01	1.03e-05



Evaluating how well STRING genes are linked to AD GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
STRING	AD GS	0.62	0.23	1.09	-0.21	1.75
AD GS	STRING	0.39	-0.73	-2.60	-1.08	-4.53

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
STRING	AD GS	0.00	-0.25	0.35	-0.48	-0.01
AD GS	STRING	0.01	-0.15	-0.83	-0.66	-1.40

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
STRING	156	153	CBWD6;HDGFL2;AC008770.2
AD GS	25	24	HLA -DRB1