Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
STRING	LBD	8.24e-01	6.12e-01	5.05e-01	2.72e-02
LBD	STRING	2.62e-08	8.93e-04	8.93e-44	1.11e-01



Evaluating how well STRING genes are linked to LBD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
STRING	LBD	0.78	0.74	1.10	0.11	2.37
LBD	STRING	0.51	6.83	4.09	2.34	0.55

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
STRING	LBD	0.00	0.07	2.90	-0.63	0.97
LBD	STRING	0.01	4.96	1.40	0.84	-0.02

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
STRING	156	153	HDGFL2;AC008770.2;CBWD6
LBD	6	6