Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AC20_EA30 Exclusive	BRCA-GWAS	1.77e-03	6.12e-03	4.28e-12	2.31e-11
BRCA-GWAS Exclusive	AC20_EA30	1.68e-05	1.07e-03	1.63e-20	5.20e-27
AC20_EA30 Exclusive	BRCA-GWAS Exclusive	1.36e-03	1.10e-02	4.25e-10	1.85e-10
BRCA-GWAS Exclusive	AC20_EA30 Exclusive	2.07e-04	2.13e-03	1.92e-18	2.21e-24
AC20_EA30 Exclusive	Overlap	2.08e-05	1.72e-04	3.45e-07	2.12e-06
BRCA-GWAS Exclusive	Overlap	3.07e-02	2.85e-01	1.33e-03	9.94e-06
Overlap	Exclusives	5.57e-32	7.49e-31	1.32e-75	1.15e-55



Evaluating how well AC20_EA30 genes are linked to BRCA-GWAS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC20_EA30 Exclusive	BRCA-GWAS	0.68	2.58	4.92	3.68	7.76
BRCA-GWAS Exclusive	AC20_EA30	0.76	1.35	4.45	2.13	11.62
AC20_EA30 Exclusive	BRCA-GWAS Exclusive	0.66	3.13	4.04	3.79	7.11
BRCA-GWAS Exclusive	AC20_EA30 Exclusive	0.75	1.15	4.60	2.14	12.22
AC20_EA30 Exclusive	Overlap	0.99	2.95	5.20	3.10	4.57
BRCA-GWAS Exclusive	Overlap	0.96	1.73	2.10	2.39	3.95
Overlap	Exclusives	0.77	3.28	14.03	3.37	16.77

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC20_EA30 Exclusive	BRCA-GWAS	0.03	2.05	19.04	9.95	17.78
BRCA-GWAS Exclusive	AC20_EA30	0.06	2.02	13.93	7.00	62.85
AC20_EA30 Exclusive	BRCA-GWAS Exclusive	0.02	-2.28	3.05	2.74	6.59
BRCA-GWAS Exclusive	AC20_EA30 Exclusive	0.05	1.07	14.14	7.97	62.16
AC20_EA30 Exclusive	Overlap	0.28	29.22	328.35	87.61	365.65
BRCA-GWAS Exclusive	Overlap	0.03	0.79	1.15	9.67	75.14
Overlap	Exclusives	0.18	16.61	125.56	32.93	159.73

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AC20_EA30 Exclusive	191	190	NME2P1
BRCA-GWAS Exclusive	166	166	
Overlap	7	7