Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AC1000_EA50 Exclusive	BRCA-Familial	2.98e-14	3.06e-10	5.21e-20	5.31e-18
BRCA-Familial Exclusive	AC1000_EA50	6.75e-12	2.46e-09	1.66e-39	2.26e-39
AC1000_EA50 Exclusive	BRCA-Familial Exclusive	1.61e-04	8.58e-04	6.07e-09	2.45e-07
BRCA-Familial Exclusive	AC1000_EA50 Exclusive	1.34e-07	7.38e-07	2.24e-32	4.08e-34
AC1000_EA50 Exclusive	Overlap	5.05e-12	5.38e-10	1.88e-13	3.72e-13
BRCA-Familial Exclusive	Overlap	1.88e-13	4.60e-13	1.88e-13	3.28e-13
Overlap	Exclusives	1.91e-10	2.32e-13	7.24e-39	1.94e-42



Evaluating how well AC1000_EA50 genes are linked to BRCA-Familial genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC1000_EA50 Exclusive	BRCA-Familial	0.99	3.20	6.86	2.84	8.34
BRCA-Familial Exclusive	AC1000_EA50	0.82	2.81	8.42	2.71	15.07
AC1000_EA50 Exclusive	BRCA-Familial Exclusive	0.97	2.16	3.36	2.55	4.94
BRCA-Familial Exclusive	AC1000_EA50 Exclusive	0.80	2.24	7.74	2.99	12.61
AC1000_EA50 Exclusive	Overlap	1.00	3.21	4.79	2.34	6.50
BRCA-Familial Exclusive	Overlap	1.00	4.63	5.70	2.83	5.98
Overlap	Exclusives	0.83	2.69	8.03	4.23	15.26

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC1000_EA50 Exclusive	BRCA-Familial	0.11	4.18	76.98	42.33	226.65
BRCA-Familial Exclusive	AC1000_EA50	0.07	6.20	34.52	14.05	84.68
AC1000_EA50 Exclusive	BRCA-Familial Exclusive	0.01	-0.12	9.79	10.04	10.85
BRCA-Familial Exclusive	AC1000_EA50 Exclusive	0.04	2.49	16.59	10.30	34.15
AC1000_EA50 Exclusive	Overlap	0.13	3.74	144.02	41.80	449.76
BRCA-Familial Exclusive	Overlap	0.13	85.20	182.18	65.90	377.14
Overlap	Exclusives	0.07	6.49	41.79	21.21	68.68

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AC1000_EA50 Exclusive	251	160	IGKV1-12;IGLV6-57;IGLV2-11;IGLV3-25;gag-pol;IGLV2-14;IGHV1-69;IGLV11-55;IGKV1D-33;IGHV3-33;IGLV3-16;IGLV;IGHV4-59;IGLV7-43;IGKV1-16;IGLV2-33;IGLV3-27;vpr;IGKV3-20;IGLV1-51;IGHV2-5;IGLV1-36;vpu;IGLC1;IGHV3-53;IGKV1D-39;IGHV;IGHV4-34;IGKV2-28;IGLV8-61;IGLV7-46;IGKV3-15;IGLV1-47;IGKV1-39;IGLV3-22;IGKV3D-20;IGHG4;IGLV4-60;IGHD;IGKV2-29;IGHV3-23;IGHV7-81;nef;IGLV2-23;IGLV3-21;IGKV1-5;IGHV2-70;IGKV5-2;env;IGLC2;IGKV2-30;IGLV5-37;IGLV3-1;IGLV1-44;IGKV2D-28;rev;IGLC7;IGHV1-46;IGKV1D-12;IGKV3-11;IGHV3-9;IGLV1-40;IGLC6;IGKV1-33;IGKV1D-16;IGHV3-13;IGLC3;IGLV10-54;IGKV4-1;gag;IGKC;IGHG3;IGHV4-39;IGLV4-3;IGLV2-18;IGHV3-7;IGHV1-2;IGHG2;IGLV3-12;IGHG1;IGLV4-69;IGKV2D-40;vif;IGLV3-19;IGHM;IGHV3-30;IGKV2D-30;IGKV1-17;IGLV2-8;IGLV5-45;IGHV3-48
BRCA-Familial Exclusive	9	9	
Overlap	14	14