Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AC20_EA30 Exclusive	BRCA-Familial	5.83e-16	9.67e-12	1.32e-19	1.28e-17
BRCA-Familial Exclusive	AC20_EA30	2.23e-17	6.11e-21	3.63e-74	1.06e-60
AC20_EA30 Exclusive	BRCA-Familial Exclusive	6.80e-06	1.30e-04	2.80e-09	1.53e-07
BRCA-Familial Exclusive	AC20_EA30 Exclusive	1.08e-15	1.62e-19	6.16e-67	3.85e-55
AC20_EA30 Exclusive	Overlap	1.45e-12	3.41e-12	1.45e-12	1.80e-12
BRCA-Familial Exclusive	Overlap	1.45e-12	3.87e-12	1.45e-12	2.14e-12
Overlap	Exclusives	4.51e-41	2.98e-38	3.59e-61	7.56e-60



Evaluating how well AC20_EA30 genes are linked to BRCA-Familial genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC20_EA30 Exclusive	BRCA-Familial	0.99	2.96	6.23	3.49	8.99
BRCA-Familial Exclusive	AC20_EA30	0.85	6.05	12.66	3.41	18.36
AC20_EA30 Exclusive	BRCA-Familial Exclusive	0.97	1.57	3.52	2.50	4.97
BRCA-Familial Exclusive	AC20_EA30 Exclusive	0.84	6.24	12.11	3.05	15.58
AC20_EA30 Exclusive	Overlap	1.00	3.34	5.69	3.04	6.97
BRCA-Familial Exclusive	Overlap	1.00	7.44	5.41	2.91	6.65
Overlap	Exclusives	0.86	3.10	13.23	4.04	17.32

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AC20_EA30 Exclusive	BRCA-Familial	0.45	29.53	573.29	186.69	927.60
BRCA-Familial Exclusive	AC20_EA30	0.12	9.61	74.32	20.98	84.10
AC20_EA30 Exclusive	BRCA-Familial Exclusive	0.01	-0.92	24.56	6.01	29.86
BRCA-Familial Exclusive	AC20_EA30 Exclusive	0.07	4.67	47.49	12.28	91.11
AC20_EA30 Exclusive	Overlap	0.71	27.92	988.76	282.75	994.50
BRCA-Familial Exclusive	Overlap	0.21	339.21	322.15	148.92	838.11
Overlap	Exclusives	0.22	24.09	184.62	56.16	169.69

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AC20_EA30 Exclusive	185	184	NME2P1
BRCA-Familial Exclusive	10	10	
Overlap	13	13