Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
72 consensus	GeneGroup2	4.20e-01	4.85e-01	3.28e-01	6.17e-03
GeneGroup2	72 consensus	3.29e-01	3.62e-01	3.78e-11	2.53e-01



Evaluating how well 72 consensus genes are linked to GeneGroup2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
72 consensus	GeneGroup2	0.85	1.51	2.19	1.88	2.92
GeneGroup2	72 consensus	0.54	1.63	0.84	0.10	1.08

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
72 consensus	GeneGroup2	0.00	0.80	2.77	1.15	1.56
GeneGroup2	72 consensus	0.00	2.08	1.83	0.85	1.42

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
72 consensus	71	71	
GeneGroup2	6	6