Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
72 consensus	AD GS	2.60e-01	5.09e-01	1.24e-01	9.25e-02
AD GS	72 consensus	9.27e-02	9.47e-01	3.98e-01	8.36e-01



Evaluating how well 72 consensus genes are linked to AD GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
72 consensus	AD GS	0.63	0.32	0.12	0.36	2.41
AD GS	72 consensus	0.52	-0.59	0.19	-0.15	0.60

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
72 consensus	AD GS	0.00	0.42	0.76	0.57	-0.05
AD GS	72 consensus	0.00	-0.16	0.19	0.21	0.71

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
72 consensus	71	71	
AD GS	25	24	HLA -DRB1