Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
consensus72	AD Ismael	4.79e-01	2.69e-01	6.37e-01	6.46e-01
AD Ismael	consensus72	4.96e-01	9.03e-01	5.62e-02	5.11e-01



Evaluating how well consensus72 genes are linked to AD Ismael genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
consensus72	AD Ismael	0.57	-1.23	-1.56	-0.91	1.00
AD Ismael	consensus72	0.53	0.49	-0.05	-0.27	1.06

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
consensus72	AD Ismael	0.00	-0.96	-1.39	-0.70	0.01
AD Ismael	consensus72	0.00	-0.43	-0.55	-0.34	0.23

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
consensus72	71	71	
AD Ismael	14	14