Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
consensus72	singleton	5.81e-03	7.00e-02	2.57e-01	1.53e-01
singleton	consensus72	1.95e-01	3.74e-01	2.98e-02	8.17e-01



Evaluating how well consensus72 genes are linked to singleton genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
consensus72	singleton	0.58	-2.40	-2.18	-1.63	1.30
singleton	consensus72	0.50	-0.62	-1.01	-1.07	-0.19

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
consensus72	singleton	0.00	-1.36	-1.52	-0.96	-0.09
singleton	consensus72	0.00	-0.43	-0.99	-1.11	-0.41

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
consensus72	71	71	
singleton	21	21