Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
72 consensus	SS Juan	2.62e-01	8.52e-01	9.66e-01	9.66e-01
SS Juan	72 consensus	2.68e-01	5.48e-01	1.90e-01	6.28e-01



Evaluating how well 72 consensus genes are linked to SS Juan genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
72 consensus	SS Juan	0.50	-1.44	-0.68	-0.56	-0.08
SS Juan	72 consensus	0.52	-0.66	-0.56	-0.55	0.43

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
72 consensus	SS Juan	0.00	-0.97	-0.53	-0.32	-0.40
SS Juan	72 consensus	0.00	-0.73	-1.13	-0.63	-0.30

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
72 consensus	71	71	
SS Juan	11	11