Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
disc	clinvar	2.63e-03	1.05e-02	2.10e-08	6.64e-08
clinvar	disc	1.19e-03	3.26e-03	1.12e-07	4.10e-12



Evaluating how well disc genes are linked to clinvar genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
disc	clinvar	0.84	5.33	5.27	3.39	5.56
clinvar	disc	0.71	-0.59	3.67	0.96	8.23

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
disc	clinvar	0.01	4.68	5.60	10.34	15.96
clinvar	disc	0.02	3.14	8.20	5.11	16.51

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
disc	128	127	BRD2
clinvar	21	21