Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Consensus2 Exclusive	Meta_Analysis	3.54e-05	1.40e-03	7.15e-05	2.08e-10
Meta_Analysis Exclusive	Consensus2	1.54e-05	1.16e-02	2.49e-05	1.04e-02
Consensus2 Exclusive	Meta_Analysis Exclusive	1.85e-05	2.06e-03	9.20e-06	1.73e-09
Meta_Analysis Exclusive	Consensus2 Exclusive	9.17e-06	2.14e-02	6.19e-05	2.00e-02
Consensus2 Exclusive	Overlap	4.35e-01	4.53e-01	1.12e-01	2.06e-01
Meta_Analysis Exclusive	Overlap	9.92e-02	1.18e-01	9.92e-02	1.12e-01
Overlap	Exclusives	1.15e-02	2.45e-03	1.58e-17	1.95e-05



Evaluating how well Consensus2 genes are linked to Meta_Analysis genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Consensus2 Exclusive	Meta_Analysis	0.89	3.11	4.88	2.53	6.77
Meta_Analysis Exclusive	Consensus2	0.56	-0.01	2.55	1.21	2.66
Consensus2 Exclusive	Meta_Analysis Exclusive	0.89	2.96	4.73	2.64	6.72
Meta_Analysis Exclusive	Consensus2 Exclusive	0.56	-0.13	2.31	1.11	2.32
Consensus2 Exclusive	Overlap	0.89	0.61	0.74	1.30	1.19
Meta_Analysis Exclusive	Overlap	0.99	1.22	1.57	1.91	1.48
Overlap	Exclusives	0.61	1.22	3.29	1.56	4.54

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Consensus2 Exclusive	Meta_Analysis	0.01	6.45	10.60	3.95	21.76
Meta_Analysis Exclusive	Consensus2	0.01	1.85	7.46	4.16	3.86
Consensus2 Exclusive	Meta_Analysis Exclusive	0.01	6.84	11.08	3.61	16.65
Meta_Analysis Exclusive	Consensus2 Exclusive	0.01	1.31	6.39	3.92	2.56
Consensus2 Exclusive	Overlap	0.00	0.01	-0.13	0.59	0.06
Meta_Analysis Exclusive	Overlap	0.00	0.41	3.25	10.06	2.27
Overlap	Exclusives	0.02	1.82	6.73	2.63	7.90

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Consensus2 Exclusive	142	140	CCDC169-SOHLH2;AL669918.1
Meta_Analysis Exclusive	25	25	
Overlap	1	1