Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Consensus2 Exclusive	Exonic_IMSGC	2.71e-04	4.76e-04	3.14e-06	5.39e-05
Exonic_IMSGC Exclusive	Consensus2	2.05e-03	2.60e-03	1.34e-04	2.08e-04
Consensus2 Exclusive	Exonic_IMSGC Exclusive	3.01e-04	1.18e-03	4.01e-06	6.63e-05
Exonic_IMSGC Exclusive	Consensus2 Exclusive	3.28e-03	4.18e-03	2.15e-04	1.62e-04
Consensus2 Exclusive	Overlap	7.93e-01	2.92e-01	6.93e-01	4.91e-01
Exonic_IMSGC Exclusive	Overlap	2.28e-01	4.72e-01	3.06e-01	8.29e-01
Overlap	Exclusives	1.28e-03	2.18e-01	4.42e-13	1.43e-03



Evaluating how well Consensus2 genes are linked to Exonic_IMSGC genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Consensus2 Exclusive	Exonic_IMSGC	0.58	3.89	4.46	3.32	5.00
Exonic_IMSGC Exclusive	Consensus2	0.59	3.24	3.38	2.82	4.00
Consensus2 Exclusive	Exonic_IMSGC Exclusive	0.58	3.12	4.41	3.36	4.99
Exonic_IMSGC Exclusive	Consensus2 Exclusive	0.59	3.23	3.37	2.99	3.83
Consensus2 Exclusive	Overlap	0.71	0.29	0.72	0.22	0.69
Exonic_IMSGC Exclusive	Overlap	0.49	-0.97	-0.54	-0.83	-0.05
Overlap	Exclusives	0.54	0.13	1.16	0.36	3.65

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Consensus2 Exclusive	Exonic_IMSGC	0.02	4.56	4.03	4.45	5.87
Exonic_IMSGC Exclusive	Consensus2	0.01	2.36	5.03	5.12	4.66
Consensus2 Exclusive	Exonic_IMSGC Exclusive	0.02	3.80	4.71	5.01	4.81
Exonic_IMSGC Exclusive	Consensus2 Exclusive	0.01	5.17	5.13	3.33	6.38
Consensus2 Exclusive	Overlap	0.00	-0.21	-0.26	-0.30	-0.12
Exonic_IMSGC Exclusive	Overlap	0.00	-0.41	-0.48	-0.53	-0.14
Overlap	Exclusives	0.02	-0.36	0.04	-0.12	1.53

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Consensus2 Exclusive	142	140	AL669918.1;CCDC169-SOHLH2
Exonic_IMSGC Exclusive	303	303	
Overlap	1	1