Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
MIGen	UKBiobank	1.54e-01	4.55e-01	2.47e-01	4.03e-01
UKBiobank	MIGen	6.07e-01	9.26e-01	4.85e-01	4.85e-01



Evaluating how well MIGen genes are linked to UKBiobank genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
MIGen	UKBiobank	0.52	0.58	0.90	0.55	0.67
UKBiobank	MIGen	0.48	0.18	0.16	0.25	-0.54

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
MIGen	UKBiobank	0.01	-0.22	0.13	-0.28	0.13
UKBiobank	MIGen	0.00	-0.20	0.17	-0.37	-0.37

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
MIGen	79	79	
UKBiobank	130	129	SYT15