Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Males	Females	1.26e-01	1.29e-01	1.50e-01	5.21e-02
Females	Males	3.90e-01	6.78e-01	4.01e-01	8.62e-01



Evaluating how well Males genes are linked to Females genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Males	Females	0.55	1.35	1.59	1.69	1.77
Females	Males	0.50	0.75	0.48	0.67	-0.21

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Males	Females	0.01	0.43	0.61	0.35	1.11
Females	Males	0.01	0.89	2.29	1.74	2.11

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Males	123	120	3-Mar;10-Sep;1-Mar
Females	98	97	MEF2BNB-MEF2B