Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EPI	GS	3.89e-01	4.40e-01	2.98e-01	5.79e-03
GS	EPI	5.14e-01	8.51e-01	8.42e-14	4.72e-01



Evaluating how well EPI genes are linked to GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI	GS	0.71	-0.37	0.45	-0.52	2.45
GS	EPI	0.48	0.21	-0.12	-0.10	-0.97

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI	GS	0.00	-0.72	-0.58	-0.95	1.15
GS	EPI	0.01	0.30	-0.57	-0.44	-1.03

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EPI	127	126	AC010255.3
GS	12	12