Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
157 genes	GS	9.05e-01	8.52e-01	9.55e-04	2.69e-04
GS	157 genes	8.27e-02	6.93e-01	1.27e-13	6.52e-09



Evaluating how well 157 genes genes are linked to GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
157 genes	GS	0.82	0.17	0.62	1.02	3.74
GS	157 genes	0.66	0.58	1.37	1.37	7.39

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
157 genes	GS	0.00	-0.06	-23.51	1.27	1.25
GS	157 genes	0.01	0.50	0.84	2.23	8.85

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
157 genes	157	157	
GS	12	12