Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ML_2_concensus	13_AD	2.63e-05	4.00e-06	3.28e-06	8.02e-09
13_AD	ML_2_concensus	1.84e-01	7.42e-02	3.04e-02	3.85e-02



Evaluating how well ML_2_concensus genes are linked to 13_AD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ML_2_concensus	13_AD	0.91	3.13	5.83	2.92	4.76
13_AD	ML_2_concensus	0.66	3.88	2.85	2.17	2.01

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ML_2_concensus	13_AD	0.00	4.62	14.42	3.64	9.88
13_AD	ML_2_concensus	0.00	9.84	5.39	3.46	3.75

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ML_2_concensus	14	14	
13_AD	14	14