Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EAML	13_GS	9.53e-02	5.39e-02	3.62e-02	3.18e-04
13_GS	EAML	3.57e-01	8.31e-03	2.01e-07	1.16e-02



Evaluating how well EAML genes are linked to 13_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML	13_GS	0.80	1.26	2.53	1.53	4.20
13_GS	EAML	0.58	4.22	3.57	3.21	2.77

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML	13_GS	0.00	0.31	0.98	0.78	2.60
13_GS	EAML	0.01	2.86	1.74	2.26	0.95

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EAML	90	90	
13_GS	14	14