Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EAML Exclusive	25_GS	1.12e-01	2.37e-01	2.13e-01	3.55e-01
25_GS Exclusive	EAML	1.88e-01	3.10e-01	2.68e-02	2.41e-01
EAML Exclusive	25_GS Exclusive	3.77e-01	3.51e-01	2.59e-01	4.32e-01
25_GS Exclusive	EAML Exclusive	1.46e-01	3.06e-01	5.13e-02	3.26e-01
EAML Exclusive	Overlap	8.28e-01	3.72e-01	8.72e-01	1.98e-01
25_GS Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.15e-02
Overlap	Exclusives	5.23e-02	7.54e-03	4.83e-28	3.56e-03



Evaluating how well EAML genes are linked to 25_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML Exclusive	25_GS	0.56	-0.86	-1.14	-0.83	1.01
25_GS Exclusive	EAML	0.53	0.61	0.78	0.82	0.96
EAML Exclusive	25_GS Exclusive	0.54	-0.66	-1.16	-0.89	0.71
25_GS Exclusive	EAML Exclusive	0.52	0.33	0.70	0.43	0.58
EAML Exclusive	Overlap	0.76	-0.19	-0.60	-0.33	1.48
25_GS Exclusive	Overlap	1.00	2.79	2.62	2.94	2.30
Overlap	Exclusives	0.61	3.08	4.78	2.50	4.76

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML Exclusive	25_GS	0.00	-0.48	-1.39	-0.74	-0.18
25_GS Exclusive	EAML	0.01	1.42	0.10	1.27	0.25
EAML Exclusive	25_GS Exclusive	0.00	-0.68	-1.30	-0.79	-0.33
25_GS Exclusive	EAML Exclusive	0.00	-0.65	-0.41	-0.51	-0.50
EAML Exclusive	Overlap	0.00	-0.33	-1.33	-0.52	-0.00
25_GS Exclusive	Overlap	0.04	78.82	215.58	220.24	85.06
Overlap	Exclusives	0.04	70.47	72.84	43.31	26.89

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EAML Exclusive	88	88	
25_GS Exclusive	23	22	HLA -DRB1
Overlap	2	2