Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EPI	13_GS	4.70e-02	6.24e-03	4.70e-02	7.14e-05
13_GS	EPI	7.71e-01	6.49e-01	1.18e-01	5.01e-01



Evaluating how well EPI genes are linked to 13_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI	13_GS	0.82	1.55	3.75	1.75	4.07
13_GS	EPI	0.50	1.72	0.77	1.20	0.06

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI	13_GS	0.00	1.99	3.83	2.28	3.76
13_GS	EPI	0.00	1.88	1.87	0.16	1.18

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EPI	34	33	AC003002.1
13_GS	14	14