Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EPI Exclusive	25_GS	7.49e-01	5.26e-01	7.49e-01	2.60e-02
25_GS Exclusive	EPI	7.10e-01	9.95e-01	5.47e-01	3.96e-01
EPI Exclusive	25_GS Exclusive	8.48e-01	7.12e-01	4.32e-01	9.65e-02
25_GS Exclusive	EPI Exclusive	7.27e-01	9.72e-01	9.51e-01	3.02e-01
EPI Exclusive	Overlap	1.78e-01	4.23e-02	2.93e-01	3.22e-02
25_GS Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.15e-02
Overlap	Exclusives	2.09e-05	5.82e-06	1.08e-13	4.04e-06



Evaluating how well EPI genes are linked to 25_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI Exclusive	25_GS	0.62	-0.23	0.48	0.12	2.26
25_GS Exclusive	EPI	0.46	0.27	-0.28	-0.21	-0.89
EPI Exclusive	25_GS Exclusive	0.59	-0.36	0.03	-0.18	1.43
25_GS Exclusive	EPI Exclusive	0.42	-0.10	-0.52	-0.48	-1.38
EPI Exclusive	Overlap	0.92	1.65	2.33	1.58	2.24
25_GS Exclusive	Overlap	1.00	2.41	2.21	2.61	2.47
Overlap	Exclusives	0.67	7.33	5.02	2.75	4.60

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI Exclusive	25_GS	0.00	-0.27	0.18	-0.19	0.67
25_GS Exclusive	EPI	0.00	3.38	0.50	3.33	4.39
EPI Exclusive	25_GS Exclusive	0.00	-0.54	-0.47	-0.45	-0.13
25_GS Exclusive	EPI Exclusive	0.00	-0.40	-0.36	-0.29	-0.21
EPI Exclusive	Overlap	0.00	2.33	7.79	2.35	1.30
25_GS Exclusive	Overlap	0.04	121.97	194.22	187.47	133.35
Overlap	Exclusives	0.08	223.63	129.03	66.23	114.28

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EPI Exclusive	32	31	AC003002.1
25_GS Exclusive	23	22	HLA -DRB1
Overlap	2	2